Vinyl silazane: The "performance enhancer" for heart stents
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Vinylsilazane, as a silane coupling agent, has demonstrated outstanding application value in the field of cardiac stents. Its core function is to form a stable coating on the surface of the stent through chemical bonding, significantly enhancing the biocompatibility and functionality of the stent, and providing a safer and more reliable solution for cardiovascular interventional therapy.
The significant improvement in anti-thrombotic performance is the core advantage of vinyl silinonium. Traditional metal stents are prone to triggering platelet aggregation and fibrin deposition, thereby increasing the risk of thrombosis. However, the vinyl silinonium coating reduces the thrombosis rate by over 60% by inhibiting the activity of coagulation factors. Clinical data show that after modification with this coating, the thrombosis rate of the stents decreased from 2.3% of traditional stents to 0.5% within 30 days after implantation, significantly reducing complications such as acute myocardial infarction.
Promoting endothelialization and reducing inflammation are its other key characteristics. The coating surface mimics the structure of natural vascular endothelium, accelerating the adhesion and proliferation of human endothelial cells, and forming a biological protective layer. At the same time, its low surface energy property can reduce the infiltration of inflammatory cells and lower the risk of postoperative proliferative stenosis. Animal experiments have shown that the intimal thickness of the modified stent is 40% less than that of the traditional stent, and the restenosis rate has decreased from 15% to below 5%.
Furthermore, the process of vinyl silazane has significant advantages. Surface modification can be achieved simply through soaking or spraying, without the need for complex chemical synthesis. The coating thickness is controllable (50-200nm), balancing performance and cost. Currently, this technology has been applied to cutting-edge products such as the "Huira®" biodegradable stent in minimally invasive medical treatment, opening up new paths for the treatment of cardiovascular diseases.